Angioedema in pediatric liver transplant recipients under tacrolimus immunosuppression Lykavieris, Panayotis; Frauger, Elisabeth; Habes, Dalila; Bernard, Olivier; Debray, Dominique
Abstract Background. The authors report on their experience with food-induced angioedema in tacrolimus-immunosuppressed pediatric liver recipients.
Methods. Among 121 children treated with tacrolimus after liver transplantation, those who presented with angioedema are reported.
Results. Twelve children (10%) experienced angioedema related to food allergy while on tacrolimus. Mean ages at transplantation and angioedema were 1.3 years and 3.75 years, respectively. Angioedema occurred within a mean of 28 months from onset of tacrolimus. Eleven children experienced two or more angioedema attacks without consequences. One child presented with anaphylactic shock that caused postischemic cerebral damage. Besides eviction of food allergens, eight children were switched from tacrolimus to cyclosporine, whereas tacrolimus dosage was decreased in four. Reintroduction of food allergens was successfully performed only in those who were switched to cyclosporine.
Conclusion. A causal relationship between tacrolimus and the occurrence of food-induced angioedema is suggested. The switch from tacrolimus to cyclosporine should be considered.
See survey below! But to see the full list of all chronic urticaria go back to the main page. http://urticariaresearch.blogspot.com/ to post or comment in areas like: your health history,Things we should know about your urticaria, diet and other information.
What type of Urticaria have you been diagnosed with?
How Often ?
How are you feeling about your condition?
Have you been sucessful in finding treatment for your Urticaria?
What type of doctor have you seen?
What lab tests have you had?
Previous history of being diagnosed with Nephritis (kidney ) infection?
Have you been hospitalized for an infection in the past?
Muscle/Joint/Jaw/Neck Pain?
Dental problems/abcess/root canals?
NEW QUESTION Contact lens developing crystals?
Digestive issues?
Any issues after receiving childhood immunizations?
Food sensitivity/?
Had a significant vision change through the years?
MRI Brain/Angioma?
Don't forget to post "your" information!!
This site is dedicated to my husband who has battled chronic urticaria for over 29 years. For more information on your type of urticaria please click on this link http://urticariaresearch.blogspot.com/ to go back to the main page and review areas DOWN THE PAGE which include: WE NEED YOUR IMPUT TO LEARN MORE ABOUT THIS CONDITION! *Your Medical history before and after chronic urticaria *Things we should know about your urticaria *Need prayer *Does location play a part? *Do you have a question? *What are your symptoms and triggers? Together we can find a cure!
Angioedema in pediatric liver transplant recipients under tacrolimus immunosuppression
ReplyDeleteLykavieris, Panayotis; Frauger, Elisabeth; Habes, Dalila; Bernard, Olivier; Debray, Dominique
Abstract
Background. The authors report on their experience with food-induced angioedema in tacrolimus-immunosuppressed pediatric liver recipients.
Methods. Among 121 children treated with tacrolimus after liver transplantation, those who presented with angioedema are reported.
Results. Twelve children (10%) experienced angioedema related to food allergy while on tacrolimus. Mean ages at transplantation and angioedema were 1.3 years and 3.75 years, respectively. Angioedema occurred within a mean of 28 months from onset of tacrolimus. Eleven children experienced two or more angioedema attacks without consequences. One child presented with anaphylactic shock that caused postischemic cerebral damage. Besides eviction of food allergens, eight children were switched from tacrolimus to cyclosporine, whereas tacrolimus dosage was decreased in four. Reintroduction of food allergens was successfully performed only in those who were switched to cyclosporine.
Conclusion. A causal relationship between tacrolimus and the occurrence of food-induced angioedema is suggested. The switch from tacrolimus to cyclosporine should be considered.