Schnitzler's Syndrome: Monoclonal Gammopathy Associated with Chronic Schnitzler's syndrome (SS) is defined by monoclonal gammopathy and chronic urticaria combined with at least two of the following features: fever, arthralgia or arthritis, bone pain, hepato- and/or splenomegaly, palpable lymph nodes, elevated ESR, and leukocytosis. We report a 49-year-old man with monoclonal IgM gammopathy and a 4-year history of recurrent urticarial rash, unexplained fever and arthralgias. The skin biopsy from an acute lesion revealed perivascular lymphocytic infiltrates consisting of CD4+ and CD8+ T lymphocytes. To our knowledge, this is the first report of an immunophenotypic characterization of skin infiltrates in SS. A lower CD4+/CD8+ ratio of circulating T lymphocytes was also detected. SS usually has a benign course, but in 15% of patients a lymphoproliferative disorder develops. Schnitzler's Syndrome: Monoclonal Gammopathy Associated with Chronic Urticaria
I have been suffering with chronic urticaria for about two years or more. I have been reading everything I could find online to try to figure out what to do about it. I've been to a dermatologist, an allergist, and my GP, but nothing they gave me did any good. Finally about 2 months ago I came across this clinical study: (http://clinicaltrials.gov/ct2/show/NCT00876369) that linked vitamin D deficiency to chronic urticaria. I had my D levels checked and my level was 9 (it is supposed to be somewhere between 40-70). I have been taking 50,000units of vitamin D2 (prescription) once a week for about 2 months and I have been completely hive-free since the second week of taking it. At first I thought it might just be a coincidence, but now going on 2 months I know it's the vitamin D that's making a difference. Just wanted to pass on some good news - I really hope such a simple fix can work on a large portion of sufferers out there.
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Autoimmune Idiopathic Urticaria
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Investigative Dermatology on diagnosing Chronic Urticaria
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Chronic Urticaria (Autoimmune Disease)
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Chronic Urticaria
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Chronic Urticaria Society
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ReplyDeleteSchnitzler's Syndrome: Monoclonal Gammopathy Associated with Chronic
ReplyDeleteSchnitzler's syndrome (SS) is defined by monoclonal gammopathy and chronic urticaria combined with at least two of the following features: fever, arthralgia or arthritis, bone pain, hepato- and/or splenomegaly, palpable lymph nodes, elevated ESR, and leukocytosis. We report a 49-year-old man with monoclonal IgM gammopathy and a 4-year history of recurrent urticarial rash, unexplained fever and arthralgias. The skin biopsy from an acute lesion revealed perivascular lymphocytic infiltrates consisting of CD4+ and CD8+ T lymphocytes. To our knowledge, this is the first report of an immunophenotypic characterization of skin infiltrates in SS. A lower CD4+/CD8+ ratio of circulating T lymphocytes was also detected. SS usually has a benign course, but in 15% of patients a lymphoproliferative disorder develops.
Schnitzler's Syndrome: Monoclonal Gammopathy Associated with Chronic Urticaria
I have been suffering with chronic urticaria for about two years or more. I have been reading everything I could find online to try to figure out what to do about it. I've been to a dermatologist, an allergist, and my GP, but nothing they gave me did any good. Finally about 2 months ago I came across this clinical study: (http://clinicaltrials.gov/ct2/show/NCT00876369) that linked vitamin D deficiency to chronic urticaria. I had my D levels checked and my level was 9 (it is supposed to be somewhere between 40-70). I have been taking 50,000units of vitamin D2 (prescription) once a week for about 2 months and I have been completely hive-free since the second week of taking it. At first I thought it might just be a coincidence, but now going on 2 months I know it's the vitamin D that's making a difference. Just wanted to pass on some good news - I really hope such a simple fix can work on a large portion of sufferers out there.
ReplyDelete