Wednesday, November 4, 2009

Bacteria linked with Chronic Urticaria

Chronic urticaria associated with bacterial infection. A case of dental infection.
Tanphaichitr K.

In most cases of chronic urticaria, a specific etiology cannot be determined. This should not discourage the physician from continuing to search for its underlying cause. Infection has long been considered a cause of urticaria, although the incidence is probably low when all other common causes are considered. A case of chronic urticaria of five years duration, which was associated with chronic extensive dental infection and periodontal disease, is presented to show the importance of infection as a trigger mechanism of urticaria.
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2 comments:

  1. sunriseNovember 4, 2009 at 9:11 PM

    Clinical and Laboratory Investigations

    Helicobacter pylori as a Possible Bacterial Focus of Chronic Urticaria
    S. Wustlicha, R. Brehlera, T.A. Lugera, T. Pohleb, W. Domschkeb, E.-C. Foersterb

    Departments of
    aDermatology and
    bMedicine B, University of Münster, Germany


    Address of Corresponding Author

    Dermatology 1999;198:130-132 (DOI: 10.1159/000018088)


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    Key Words

    Helicobacter pylori
    Eradication therapy
    Chronic urticaria

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    Abstract

    Background: Chronic urticaria is one of the most frequent skin diseases. Its cause, however, remains unsolved in a large number of cases. Recent investigations pointed to a potential role of Helicobacter pylori infection of the upper gastrointestinal tract as a possible causative agent in chronic urticaria. Objective: The aim of this study was to examine the effect of a 14-day eradication therapy on chronic urticaria. Methods: Thirty patients with chronic urticaria and confirmed H. pylori infection were treated with amoxicillin and omeprazole. Follow-up was conducted over a period of 6 months concerning eradication of H. pylori and remission of urticaria. Results: Only 8 out of 30 patients (26.7%) showed clinical improvement or disappearance of their urticarial symptoms. Conclusion: Though our results do not support the preliminary data of previous studies, the role of H. pylori as a possible bacterial focus of chronic urticaria has to be further investigated.


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    Author Contacts

    Dr. S. Wustlich
    Universitäts-Hautklinik
    Von-Esmarch-Strasse 56
    D-48149 Münster (Germany)
    Tel. +49 251 8356504, Fax +49 251 8356522

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  2. sunriseNovember 4, 2009 at 9:15 PM

    2006 Sep-Oct;53(5):174-8.

    [Frequency of Helicobacter pylori infection in patients with chronic urticaria of Puebla University Hospital]
    [Article in Spanish]

    Cuevas Acuña MT, López García AI, Paz Martínez D, Galindo García JA, Papaqui Tapia S, Garza Yado Mde L, Arana Muñoz O, Palacios Flores C, Pérez Fernández S.

    Hospital Universitario de Puebla, Servicio de alergia e inmunología clínica, 25 Poniente y 13 Sur, colonia Los Volcanes, CP 72410, Puebla.

    BACKGROUND: Chronic urticaria may be continuous or recurrent according to its form of appearance. Within the diseases associated to chronic urticaria there are mycosis, parasitism and bacterial infections where Helicobacter pylori stands out. This has been related to the allergic diseases promoting a Th2 response. OBJECTIVE: To determine the frequency of infection caused by Helicobacter pylori in patients with chronic urticaria of the allergic and clinical immunology service of the Puebla University Hospital. PATIENTS AND METHODS: A descriptive, cross-sectional, prolective and observational study was made in adult patients, between 18 and 60 years old, with diagnosis of chronic urticaria. Inhalated and food skin prick test were made to all the patients. The infection by Helicobacter pylori was documented by serology, fecal antigen, endoscopy with fast test of urease and histological study. Descriptive statistics was implemented such as frequency, percentage, central tendency and dispersion measures. RESULTS: 30 patients were included; 83.3% were women. The average age was 37.8 years (SD 13.2). The most frequent type of chronic urticaria was the persistent one, representing 56.7%. The frequency of positivism of IgG antibodies against Helicobacter pylori represented the 60.0%, for IgM 33.3% and for fecal antigen 60.0%, the combined IgG, IgM, fecal antigen, fast test of ureasa and histological study was of 83%. Conclusion: The high frequency of infection caused by Helicobacter pylori in the patient with chronic urticaria suggests a possible role in its etiopathogeny, extending the therapeutic possibilities.

    PMID: 17357563 [PubMed - indexed for MEDLINE]

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