736 Investigation of chronic urticaria with autoimmune thyroid disease and RBL cell degranulation Journal of Allergy and Clinical Immunology, Volume 97, Issue 1, Pages 366-366 A. Finn, G. Balakrishan, S. Reddigari, A. Kaplan
Infectious myositis may be caused by a broad range of bacterial, fungal, parasitic, and viral agents. Infectious myositis is overall uncommon given the relative resistance of the musculature to infection. For example, inciting events, including trauma, surgery, or the presence of foreign bodies or devitalized tissue, are often present in cases of bacterial myositis. Bacterial causes are categorized by clinical presentation, anatomic location, and causative organisms into the categories of pyomyositis, psoas abscess, Staphylococcus aureus myositis, group A streptococcal necrotizing myositis, group B streptococcal myositis, clostridial gas gangrene, and nonclostridial myositis. Fungal myositis is rare and usually occurs among immunocompromised hosts. Parasitic myositis is most commonly a result of trichinosis or cystericercosis, but other protozoa or helminths may be involved. A parasitic cause of myositis is suggested by the travel history and presence of eosinophilia. Viruses may cause diffuse muscle involvement with clinical manifestations, such as benign acute myositis (most commonly due to influenza virus), pleurodynia (coxsackievirus B), acute rhabdomyolysis, or an immune-mediated polymyositis. The diagnosis of myositis is suggested by the clinical picture and radiologic imaging, and the etiologic agent is confirmed by microbiologic or serologic testing. Therapy is based on the clinical presentation and the underlying pathogen.
A patient with cutaneous necrotizing vasculitis had chronic urticaria associated with multiple system involvement including arthralgias, glomerulonephritis, myositis, pseudotumor cerebri, and adenopathy. Persistent hypocomplementemia is noted with classic pathway activation. The syndrome recognized in this patient and those few individuals reported previously seems to constitute a distinct category of collagen-vascular disease.
(JAMA 236:2065-2068, 1976)
Author Affiliations
From the departments of medicine, dermatology, neurology, and pathology, Harvard Medical School; departments of medicine (Drs Feig and Yager), neurology (Dr Caplan), and pathology (Dr Rosen), Beth Israel Hospital; and Division of Dermatology (Dr Soter), Robert Breck Brigham Hospital, Boston. Dr Feig is now with the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
this was posted in epinions in January of 2006 My Experience of Polymyositis Jan 19 '06
Polymyositis (PM) is a weakness and degeneration of the muscles and is a very rare chronic connective tissue disease which can show different signs and symptoms from person to person. It is thought to be an autoimmune disease which can continue to attack the body's own normal and healthy tissues after fighting infections and viruses that have caused swelling, weakness, degeneration and inflammation to the muscles. It is believed that some medicines may trigger autoantibodies and white blood cells in the blood to attack the muscles after a viral infection and leads to degeneration of the muscle. Diagnosis takes several months with plenty of tests, which include physical examinations, biopsies, electromyography and many more. Treatment can vary depending on the individual but Steroids will be given in high doses to begin with and you can be on these for a long time if not indefinitely. If you have Polymyositis the chances of your children being affected is very small.
It all started for me in June 2004 with an itch. I had an itchy chest that would not go away with constantly scratching and I soon had a very sore and red chest area. The only relief was to soothe the area with a cloth soaked in iced water. The whole experience lasted approximately 5 hours and I would not of wished this on my enemy. As soon as possible I got to see my Doctor who said I had a severe reaction to something and gave me some cream. Two days later it came back just as bad as the first time and I applied the cream which was useless so it was back to the iced cloth. This itch I had for a whole year and lasted for between three and five days out of every ten days, it appeared mainly on the chest and abdomen, arms, thighs and head. During the year I got to see the consultant at the Dermatology department and he put me through a thorough M.O.T. test. This included a Biopsy done under local anaesthesia, a CT scan, an ultrasound, (which revealed an Aortic Aneurysm), and lots of blood tests. I was put on Steroids and given new creams to try but the itch stayed, the latest cream I was given did help slightly it is called Menthol .25% in Aqueous. The condition, after doing all the tests, was found to be Chronic Urticaria.
Urticaria is like Hives or Nettlerash and can last a long time from months up to decades and Doctors don't know the cause of it. Histamine in the skin is just one of the substances that cause Urticaria, so Antihistamine tablets form the main part of my treatment and I don't think they help at all. I have had many sleepless nights as the itching normally rears its ugly head after five in the evening and can last for up to four or five days. You hide yourself away from everyone and cover the area with cream that you have to wipe off after fifteen minutes because the cream has got hot from your skin and this also irritates you. You really want to give it all in, I just think a weaker person would want to end it all. Your social life is none existent and my stress levels reach the maximum at times. The Steroids do help you with the stress but after being on them for a while the side effects from them are more detrimental to my health and the Doctor will stop them.
Urticaria is like Hives or Nettlerash and can last a long time from months up to decades and Doctors don't know the cause of it. Histamine in the skin is just one of the substances that cause Urticaria, so Antihistamine tablets form the main part of my treatment and I don't think they help at all. I have had many sleepless nights as the itching normally rears its ugly head after five in the evening and can last for up to four or five days. You hide yourself away from everyone and cover the area with cream that you have to wipe off after fifteen minutes because the cream has got hot from your skin and this also irritates you. You really want to give it all in, I just think a weaker person would want to end it all. Your social life is none existent and my stress levels reach the maximum at times. The Steroids do help you with the stress but after being on them for a while the side effects from them are more detrimental to my health and the Doctor will stop them.
From October 2004 my muscles seemed to be getting weaker and I was getting a lot of chest infections, normal day to day tasks were getting more tiring. I was on a special diet of not eating food with additives and colourants, which meant cutting out a lot of food that I would normally eat. My itching was getting less frequent which was a big relief I was referred to the Respiratory Consultant who did lots more tests which resulted in the diagnosis of Pulmonary Fibrosis, so back to the Steroids with the addition of Antibiotics. Another problem that a cause is not known, I did smoke for thirty five years but I was told this was not the cause. The muscle weakness was put down to the stresses and strains of the Urticaria and the lung problems as well as the high doses of drugs that I was on.
We had a holiday to Egypt booked over a year ago and I was determined to go, and go we did in May 2005. I never itched once during our two weeks there, must of been the hot weather, but I got extremely weak and found it hard to get out of bed in the mornings. I also was finding swallowing difficult and would constantly swallow things, (mainly liquid), down the wrong way, this had been most embarrassing at times. My very worried wife had to help dress me and walk with me to the restaurant for meals, this was getting more and more exhausting as the days went on. We were thinking of going home early but decided to stay. When we got to the airport I had to have a wheelchair all the way to the plane and when we landed in England. Luckily I had another appointment with the respiratory Consultant five days after we got back and he admitted me to hospital immediately.
I was very weak by now and was losing weight even though my appetite was still good, I had lost two and a half stone in three months leading up to being admitted. I was back on a very high dose of Steroids which I had through a drip. Lots more tests had to be done these included blood tests and one of theses is called the Creatine Phosphokinase Test or CK Test. This checks the levels of enzymes in the blood, most of the CK in the body exists in the muscle so a rise in CK in the blood suggests muscle damage. My CK level was at a staggering 6000, for a healthy adult the CK level in the blood, (normal range), is 22 to 198 U/L (units per litre). Another blood test picked up high blood sugar so I now have Diabetes this was caused by the Steroids. Myositis was suggested, this is simply muscle inflammation but more tests need to be done first. An electromyogram (EMG) was a test that I had that measures the activities of the muscle by inserting a small metal needle into the muscle and records impulses. Recordings are made when the muscle is resting and contracting, this is repeated on several parts of the muscle. My muscle biopsy, which was extremely painful, was sent to London and they were then certain that I had Polymyositis.
I spent four weeks in hospital in a six bed rheumatology ward with my bed next to the window, I used to sit by my bed daily and people came in the ward and said how well I looked. The very deep tan that I had got in Egypt made me look healthier, if only they new how I really felt. They decided to put me on a drug called cyclophosphamide, used in chemotherapy, and gave me it by drip. This drug is very powerful and it is used in a wide variety of cancers, it shuts down my immune system to help speed up the recovery of the muscles but leaves me wide open to infections and nothing to fight them off. So I then had to have the Flu and Pneumovax injections. Some side effects include decreased production of blood cells by the bone marrow, inflammation of the bladder causing bleeding and can also give you hair loss. This drug with the Steroids seemed to help and my CK level started to come down. I still found it hard to swallow properly because my throat muscles had wasted away but with practice I was ok.
Back home now but needing a wheelchair to go anywhere. My eyesight has really got a lot worse now and I can't climb our stairs, I'm not able to raise one foot higher than five inches, and I need help standing up and getting dressed. I did need help getting in and out of the bath but now have an inflatable seat to assist me. I did get a bad attack of Pneumonia, even though I've had the Pneumovax jab, and had to spend another week in hospital. Although my CK is still on the way back to normal this will mean finding a happy medium with the drugs to keep my CK levels somewhere near to normal. Excercise has been a problem because of the Pulmonary Fibrosis, the more I excercise the more oxygen my muscles need which leaves me gasping for air and puts a lot of pressure on my lungs. If I went down on one knee I would not be able to get back up, that's how bad my muscles are. I've piled on the weight now because of the Steroids, how long I'm on these drugs for? well no one knows. Just got to get my Aneurysm sorted out then I can stop worrying.
If anyone is interested or affected by Myositis or Polymyositis try this link:-http://www.arc.org.uk/about_arth/booklets/6009/6009.htm Useful addresses The Arthritis Research Campaign (arc) PO Box 177, Chesterfield Derbyshire S41 7TQ Phone: 440870 850 5000 Arthritis Care 18 Stephenson Way London NW1 2HD Phone: 44020 7380 6500 Helplines: 44020 7380 6555 (10amנpm Mon–Fri) or freephone: 440808 800 4050 (12pmנpm Mon–Fri) Myositis Support Group 146 Newtown Road Woolston
See survey below! But to see the full list of all chronic urticaria go back to the main page. http://urticariaresearch.blogspot.com/ to post or comment in areas like: your health history,Things we should know about your urticaria, diet and other information.
What type of Urticaria have you been diagnosed with?
How Often ?
How are you feeling about your condition?
Have you been sucessful in finding treatment for your Urticaria?
What type of doctor have you seen?
What lab tests have you had?
Previous history of being diagnosed with Nephritis (kidney ) infection?
Have you been hospitalized for an infection in the past?
Muscle/Joint/Jaw/Neck Pain?
Dental problems/abcess/root canals?
NEW QUESTION Contact lens developing crystals?
Digestive issues?
Any issues after receiving childhood immunizations?
Food sensitivity/?
Had a significant vision change through the years?
MRI Brain/Angioma?
Don't forget to post "your" information!!
This site is dedicated to my husband who has battled chronic urticaria for over 29 years. For more information on your type of urticaria please click on this link http://urticariaresearch.blogspot.com/ to go back to the main page and review areas DOWN THE PAGE which include: WE NEED YOUR IMPUT TO LEARN MORE ABOUT THIS CONDITION! *Your Medical history before and after chronic urticaria *Things we should know about your urticaria *Need prayer *Does location play a part? *Do you have a question? *What are your symptoms and triggers? Together we can find a cure!
736 Investigation of chronic urticaria with autoimmune thyroid disease and RBL cell degranulation
ReplyDeleteJournal of Allergy and Clinical Immunology, Volume 97, Issue 1, Pages 366-366
A. Finn, G. Balakrishan, S. Reddigari, A. Kaplan
Infectious myositis may be caused by a broad range of bacterial, fungal, parasitic, and viral agents. Infectious myositis is overall uncommon given the relative resistance of the musculature to infection. For example, inciting events, including trauma, surgery, or the presence of foreign bodies or devitalized tissue, are often present in cases of bacterial myositis. Bacterial causes are categorized by clinical presentation, anatomic location, and causative organisms into the categories of pyomyositis, psoas abscess, Staphylococcus aureus myositis, group A streptococcal necrotizing myositis, group B streptococcal myositis, clostridial gas gangrene, and nonclostridial myositis. Fungal myositis is rare and usually occurs among immunocompromised hosts. Parasitic myositis is most commonly a result of trichinosis or cystericercosis, but other protozoa or helminths may be involved. A parasitic cause of myositis is suggested by the travel history and presence of eosinophilia. Viruses may cause diffuse muscle involvement with clinical manifestations, such as benign acute myositis (most commonly due to influenza virus), pleurodynia (coxsackievirus B), acute rhabdomyolysis, or an immune-mediated polymyositis. The diagnosis of myositis is suggested by the clinical picture and radiologic imaging, and the etiologic agent is confirmed by microbiologic or serologic testing. Therapy is based on the clinical presentation and the underlying pathogen.
ReplyDeleteA patient with cutaneous necrotizing vasculitis had chronic urticaria associated with multiple system involvement including arthralgias, glomerulonephritis, myositis, pseudotumor cerebri, and adenopathy. Persistent hypocomplementemia is noted with classic pathway activation. The syndrome recognized in this patient and those few individuals reported previously seems to constitute a distinct category of collagen-vascular disease.
ReplyDelete(JAMA 236:2065-2068, 1976)
Author Affiliations
From the departments of medicine, dermatology, neurology, and pathology, Harvard Medical School; departments of medicine (Drs Feig and Yager), neurology (Dr Caplan), and pathology (Dr Rosen), Beth Israel Hospital; and Division of Dermatology (Dr Soter), Robert Breck Brigham Hospital, Boston. Dr Feig is now with the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
JAMA
this was posted in epinions in January of 2006
ReplyDeleteMy Experience of Polymyositis
Jan 19 '06
Polymyositis (PM) is a weakness and degeneration of the muscles and is a very rare chronic connective tissue disease which can show different signs and symptoms from person to person. It is thought to be an autoimmune disease which can continue to attack the body's own normal and healthy tissues after fighting infections and viruses that have caused swelling, weakness, degeneration and inflammation to the muscles. It is believed that some medicines may trigger autoantibodies and white blood cells in the blood to attack the muscles after a viral infection and leads to degeneration of the muscle. Diagnosis takes several months with plenty of tests, which include physical examinations, biopsies, electromyography and many more. Treatment can vary depending on the individual but Steroids will be given in high doses to begin with and you can be on these for a long time if not indefinitely. If you have Polymyositis the chances of your children being affected is very small.
It all started for me in June 2004 with an itch. I had an itchy chest that would not go away with constantly scratching and I soon had a very sore and red chest area. The only relief was to soothe the area with a cloth soaked in iced water. The whole experience lasted approximately 5 hours and I would not of wished this on my enemy. As soon as possible I got to see my Doctor who said I had a severe reaction to something and gave me some cream. Two days later it came back just as bad as the first time and I applied the cream which was useless so it was back to the iced cloth. This itch I had for a whole year and lasted for between three and five days out of every ten days, it appeared mainly on the chest and abdomen, arms, thighs and head. During the year I got to see the consultant at the Dermatology department and he put me through a thorough M.O.T. test. This included a Biopsy done under local anaesthesia, a CT scan, an ultrasound, (which revealed an Aortic Aneurysm), and lots of blood tests. I was put on Steroids and given new creams to try but the itch stayed, the latest cream I was given did help slightly it is called Menthol .25% in Aqueous. The condition, after doing all the tests, was found to be Chronic Urticaria.
Urticaria is like Hives or Nettlerash and can last a long time from months up to decades and Doctors don't know the cause of it. Histamine in the skin is just one of the substances that cause Urticaria, so Antihistamine tablets form the main part of my treatment and I don't think they help at all. I have had many sleepless nights as the itching normally rears its ugly head after five in the evening and can last for up to four or five days. You hide yourself away from everyone and cover the area with cream that you have to wipe off after fifteen minutes because the cream has got hot from your skin and this also irritates you. You really want to give it all in, I just think a weaker person would want to end it all. Your social life is none existent and my stress levels reach the maximum at times. The Steroids do help you with the stress but after being on them for a while the side effects from them are more detrimental to my health and the Doctor will stop them.
Urticaria is like Hives or Nettlerash and can last a long time from months up to decades and Doctors don't know the cause of it. Histamine in the skin is just one of the substances that cause Urticaria, so Antihistamine tablets form the main part of my treatment and I don't think they help at all. I have had many sleepless nights as the itching normally rears its ugly head after five in the evening and can last for up to four or five days. You hide yourself away from everyone and cover the area with cream that you have to wipe off after fifteen minutes because the cream has got hot from your skin and this also irritates you. You really want to give it all in, I just think a weaker person would want to end it all. Your social life is none existent and my stress levels reach the maximum at times. The Steroids do help you with the stress but after being on them for a while the side effects from them are more detrimental to my health and the Doctor will stop them.
ReplyDeleteFrom October 2004 my muscles seemed to be getting weaker and I was getting a lot of chest infections, normal day to day tasks were getting more tiring. I was on a special diet of not eating food with additives and colourants, which meant cutting out a lot of food that I would normally eat. My itching was getting less frequent which was a big relief I was referred to the Respiratory Consultant who did lots more tests which resulted in the diagnosis of Pulmonary Fibrosis, so back to the Steroids with the addition of Antibiotics. Another problem that a cause is not known, I did smoke for thirty five years but I was told this was not the cause. The muscle weakness was put down to the stresses and strains of the Urticaria and the lung problems as well as the high doses of drugs that I was on.
We had a holiday to Egypt booked over a year ago and I was determined to go, and go we did in May 2005. I never itched once during our two weeks there, must of been the hot weather, but I got extremely weak and found it hard to get out of bed in the mornings. I also was finding swallowing difficult and would constantly swallow things, (mainly liquid), down the wrong way, this had been most embarrassing at times. My very worried wife had to help dress me and walk with me to the restaurant for meals, this was getting more and more exhausting as the days went on. We were thinking of going home early but decided to stay. When we got to the airport I had to have a wheelchair all the way to the plane and when we landed in England. Luckily I had another appointment with the respiratory Consultant five days after we got back and he admitted me to hospital immediately.
ReplyDeleteI was very weak by now and was losing weight even though my appetite was still good, I had lost two and a half stone in three months leading up to being admitted. I was back on a very high dose of Steroids which I had through a drip. Lots more tests had to be done these included blood tests and one of theses is called the Creatine Phosphokinase Test or CK Test. This checks the levels of enzymes in the blood, most of the CK in the body exists in the muscle so a rise in CK in the blood suggests muscle damage. My CK level was at a staggering 6000, for a healthy adult the CK level in the blood, (normal range), is 22 to 198 U/L (units per litre). Another blood test picked up high blood sugar so I now have Diabetes this was caused by the Steroids. Myositis was suggested, this is simply muscle inflammation but more tests need to be done first. An electromyogram (EMG) was a test that I had that measures the activities of the muscle by inserting a small metal needle into the muscle and records impulses. Recordings are made when the muscle is resting and contracting, this is repeated on several parts of the muscle. My muscle biopsy, which was extremely painful, was sent to London and they were then certain that I had Polymyositis.
I spent four weeks in hospital in a six bed rheumatology ward with my bed next to the window, I used to sit by my bed daily and people came in the ward and said how well I looked. The very deep tan that I had got in Egypt made me look healthier, if only they new how I really felt. They decided to put me on a drug called cyclophosphamide, used in chemotherapy, and gave me it by drip. This drug is very powerful and it is used in a wide variety of cancers, it shuts down my immune system to help speed up the recovery of the muscles but leaves me wide open to infections and nothing to fight them off. So I then had to have the Flu and Pneumovax injections. Some side effects include decreased production of blood cells by the bone marrow, inflammation of the bladder causing bleeding and can also give you hair loss. This drug with the Steroids seemed to help and my CK level started to come down. I still found it hard to swallow properly because my throat muscles had wasted away but with practice I was ok.
ReplyDeleteBack home now but needing a wheelchair to go anywhere. My eyesight has really got a lot worse now and I can't climb our stairs, I'm not able to raise one foot higher than five inches, and I need help standing up and getting dressed. I did need help getting in and out of the bath but now have an inflatable seat to assist me. I did get a bad attack of Pneumonia, even though I've had the Pneumovax jab, and had to spend another week in hospital. Although my CK is still on the way back to normal this will mean finding a happy medium with the drugs to keep my CK levels somewhere near to normal. Excercise has been a problem because of the Pulmonary Fibrosis, the more I excercise the more oxygen my muscles need which leaves me gasping for air and puts a lot of pressure on my lungs. If I went down on one knee I would not be able to get back up, that's how bad my muscles are. I've piled on the weight now because of the Steroids, how long I'm on these drugs for? well no one knows. Just got to get my Aneurysm sorted out then I can stop worrying.
If anyone is interested or affected by Myositis or Polymyositis try this link:-http://www.arc.org.uk/about_arth/booklets/6009/6009.htm
Useful addresses
The Arthritis Research Campaign (arc)
PO Box 177, Chesterfield
Derbyshire S41 7TQ
Phone: 440870 850 5000
Arthritis Care
18 Stephenson Way
London NW1 2HD
Phone: 44020 7380 6500
Helplines: 44020 7380 6555 (10amנpm Mon–Fri)
or freephone: 440808 800 4050 (12pmנpm Mon–Fri)
Myositis Support Group
146 Newtown Road
Woolston